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Understanding GS-441524: Pain Levels in Cats during FIP Treatment

Updated: Nov 15, 2023

Feline infectious peritonitis (FIP) is a severe and often fatal disease caused by a feline coronavirus. Recent studies have indicated that GS-441524, a medication developed by Gilead Sciences, can effectively treat FIP.



In this article examines the components used in the manufacturing process of GS-441524 and how they can affect pain levels in cats during treatment.


Published by: https://journals.sagepub.com



Component 1: Ethanol 5%

Ethanol, also known as ethyl alcohol, is a common type of alcohol used in many industries, including medicine. When used in injectable drugs, the amount of ethanol should not exceed 10%, and the injection volume should not exceed 20 milliliters per injection. Although ethanol is generally considered mild, it can cause a stinging sensation when applied to wounds. When injected under the skin of a cat, it can trigger a sensation of heat or burning due to cats' unique chemistry.


Component 2: Propylene Glycol (PG) 30%

Propylene Glycol (PG) is a solvent that is sometimes used in injectable medications to dissolve and transport the active drug ingredient. PG is often used as a co-solvent with water to increase the solubility of drugs. It can act as a stabilizer for certain drugs, preventing the active ingredient from degrading over time. The injection of Propylene Glycol is generally not known to cause any pain or discomfort.





Component 3: PEG400 45%

PEG400 is a clear, colorless, and slightly viscous liquid that serves as a solvent, vehicle, or excipient in various applications. It is commonly used in the pharmaceutical industry as a solvent to dissolve or suspend active ingredients and as a vehicle or excipient to enhance drug delivery and bioavailability. In the context of injectable medications, PEG400 is generally considered safe and well-tolerated.


Component 4: Water - pH1.5 with HCI 20%

Water with a pH of 1.5 with HCI 20% is highly acidic and not commonly found in natural sources of water. It can be produced through chemical processes or electrolysis. Injecting a substance with a very low pH can be very painful and potentially damaging to tissues. Highly acidic solutions can cause chemical burns and inflammation when they come into contact with living tissue.


It is important to note that administering GS-441524 may cause pain. Medications that cause little to no pain do not exist. However, the use of these components in GS-441524 has been carefully formulated by Gilead Sciences and has been found to be well-tolerated by cats without significant pain or discomfort when administered according to proper dosing and administration guidelines.





Luckily, there is now capsule available that is painless and safe. This means that pet owners can rest easy knowing that their furry friends can receive the treatment they need without experiencing any unnecessary pain or discomfort.


In conclusion, before considering GS-441524 as a treatment option for Feline infectious peritonitis, it is essential to understand the components used in its manufacturing process. While the medication has been effective in treating the disease, it may cause pain during administration.


The composition of GS-441524 includes Ethanol, Propylene Glycol, PEG400, and water with a pH of 1.5, which can cause pain and discomfort when injected into living tissue. Nonetheless, GS-441524 has been found to be well-tolerated by cats without significant pain or discomfort when administered according to proper dosing and administration guidelines.




Important Note: This article aims to provide information about GS-441524 for the purpose of enabling individuals to make an informed decision in relation to their pets. It is recommended that individuals consult with their veterinarian and thoroughly consider all information before deciding to use this medication.


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